Tottenham are boosted by the return of Dele Alli and Lucas Moura after suspension and injury respectively, while Jan Vertonghen and Michel Vorm have signed new short-term deals.
Defenders Japhet Tanganga and Juan Foyth remain sidelined.
West Ham centre-back Angelo Ogbonna has returned to training and is being assessed.
Forward Sebastian Haller again looks set to miss out, as does Robert Snodgrass due to an ongoing back issue.
- Tottenham could complete the league double over West Ham for the first time since 2012-13.
- West Ham are looking to secure back-to-back away league wins at Spurs for the first time since November 1966.
- The away side has won six of the past seven meetings in all competitions, including each of the last four.
- Spurs are winless in seven games in all competitions.
- They have gone four matches without a victory at the Tottenham Hotspur Stadium, having previously won eight of 10 home fixtures.
- Tottenham are in danger of losing three successive London league derbies for the first time since August 2005.
- They have kept four league clean sheets this term, the joint fewest in the division along with Bournemouth.
- Harry Kane has scored 29 goals in 47 Premier League London derby matches – only Thierry Henry (43), Frank Lampard (32) and Teddy Sheringham (32) have scored more.
West Ham United
- West Ham have the division’s worst record over the past eight games, with four points and one win.
- The Hammers have lost six successive away league matches and conceded 13 goals in the process.
- Their sole clean sheet in 13 leagues fixtures came in a 4-0 win over fellow strugglers Bournemouth on New Year’s Day.
- West Ham’s record of 17 losses from their opening 30 league fixtures is their most since they suffered 19 at this stage of the 2006-07 season.
- The Hammers have lost 14 of 17 matches against the current top-10 sides this season.
- Michail Antonio has scored four goals in six league appearances against Tottenham.